Which two enteroviruses are strongly suspected of causing Acute Flaccid Myelitis (AFM)?

Acute Flaccid Myelitis (AFM) is a rare neurological condition that primarily affects children and is characterized by sudden muscle weakness and paralysis. Among the various enteroviruses studied in relation to AFM, EV-D68 and EV-A71 have been strongly implicated as significant contributors to the condition.

EV-D68, a member of the enterovirus D species, has been particularly noted for its association with respiratory illness and has shown a clear epidemiological connection to outbreaks of AFM. Studies have found a higher incidence of AFM in children who have been infected with EV-D68, especially during peaks of respiratory illness in summer and fall months.

EV-A71 is also recognized for its neurological complications, including meningitis and encephalitis, leading researchers to investigate its role in AFM. While not as prominently associated as EV-D68, there is enough clinical data to suspect that it could contribute to AFM cases in some instances.

The other options do not have the same level of corroborating evidence linking them to the incidence of AFM as strongly as EV-D68 and EV-A71 do. This understanding is essential for health professionals monitoring enteroviral diseases and striving to understand and mitigate impacts on affected populations.